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| 카탈로그 번호 | MV388014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse FOXP3 Polyclonal Antibody (MV388014) is a rabbit polyclonal antibody detecting FOXP3 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Human, Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse FOXP3 (Ser189-Lys276). | ||||||||
| 타겟 | Forkhead box protein P3, IPEX, Scurfin, FOXP3 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q99JB6 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. 1. Song, X. et al. (2012) Cell reports 1, 665-75. PMID: 22813742 2. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 3. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 4. Zhou, L. et al. (2008) Nature 453, 236-40. PMID: 18368049 5. Pan, F. et al. (2009) Science (New York, N.Y.) 325, 1142-6. PMID: 19696312 | ||||||||
| 참고사항 | For research use only. |
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