Anti-Mouse LRRK2/Dardarin Polyclonal Antibody (MV789014)

Name: Anti-Mouse LRRK2/Dardarin Polyclonal Antibody
Brand: abinScience
SKU: MV789014
Price: 168 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD): --

사양:

50ug
100ug

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호

MV789014

설명

Anti-Mouse LRRK2/Dardarin Polyclonal Antibody (MV789014) is a rabbit polyclonal antibody detecting Lrrk2. Suitable for Mouse.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse LRRK2/Dardarin (Ile2151-Leu2500).

타겟

EC:2.7.11.1, EC:3.6.5.-, Leucine-rich repeat serine/threonine-protein kinase 2, Lrrk2

내독소 수준

Please contact with the lab for this information.

순도

>95% as determined by SDS-PAGE.

정제

Purified by antigen affinity column.

등록번호

Q5S006

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2/Dardarin) is a ~284 kDa protein. Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking. Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation. Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43. Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A. Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A.

1. Steger, M. et al. (2016) eLife 5. PMID: 26824392

2. Chen, ZC. et al. (2017) Science signaling 10. PMID: 28720718

3. Steger, M. et al. (2017) eLife 6. PMID: 29125462

4. Purlyte, E. et al. (2018) The EMBO journal 37, 1-18. PMID: 29212815

5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148

6. Cho, HJ. et al. (2014) The EMBO journal 33, 2314-31. PMID: 25201882

7. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Mouse LRRK2/Dardarin Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse LRRK2/Dardarin Polyclonal Antibody (MV789014)

개요

이미지

참고 문헌

데이터시트

SDS