Mouse LRRK2/Dardarin Recombinant Protein (N-His) (MV789012)

Name: Mouse LRRK2/Dardarin Recombinant Protein (N-His)
Brand: abinScience
SKU: MV789012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MV789012
Description	Recombinant Mouse LRRK2/Dardarin Protein, N-His (MV789012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q5S006
Protein length	Ile2151-Leu2500
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.7.11.1, EC:3.6.5.-, Leucine-rich repeat serine/threonine-protein kinase 2, Lrrk2
Background	Leucine-rich repeat serine/threonine-protein kinase 2 is a ~284 kDa protein. Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking. Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation. Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43. Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A. Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A. 1. Steger, M. et al. (2016) eLife 5. PMID: 26824392 2. Chen, ZC. et al. (2017) Science signaling 10. PMID: 28720718 3. Steger, M. et al. (2017) eLife 6. PMID: 29125462 4. Purlyte, E. et al. (2018) The EMBO journal 37, 1-18. PMID: 29212815 5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148 6. Cho, HJ. et al. (2014) The EMBO journal 33, 2314-31. PMID: 25201882 7. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220
Note	For research use only

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Mouse LRRK2/Dardarin Recombinant Protein (N-His).pdf

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Mouse LRRK2/Dardarin Recombinant Protein (N-His) (MV789012)

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