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Anti-Mouse LRRK2/Dardarin Polyclonal Antibody (MV789014)

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Overview
Catalog No.MV789014
Description
Anti-Mouse LRRK2/Dardarin Polyclonal Antibody (MV789014) is a rabbit polyclonal antibody detecting Lrrk2. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse LRRK2/Dardarin (Ile2151-Leu2500).
Target EC:2.7.11.1, EC:3.6.5.-, Leucine-rich repeat serine/threonine-protein kinase 2, Lrrk2
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q5S006
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2/Dardarin) is a ~284 kDa protein. Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking. Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation. Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43. Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A. Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A.

1. Steger, M. et al. (2016) eLife 5. PMID: 26824392
2. Chen, ZC. et al. (2017) Science signaling 10. PMID: 28720718
3. Steger, M. et al. (2017) eLife 6. PMID: 29125462
4. Purlyte, E. et al. (2018) The EMBO journal 37, 1-18. PMID: 29212815
5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148
6. Cho, HJ. et al. (2014) The EMBO journal 33, 2314-31. PMID: 25201882
7. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220
Note For research use only
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Anti-Mouse LRRK2/Dardarin Polyclonal Antibody

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