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Anti-Mouse LRRK2/Dardarin Polyclonal Antibody (MV789014)

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Overview
Catalog No.MV789014
Description
Anti-Mouse LRRK2/Dardarin Polyclonal Antibody (MV789014) is a rabbit polyclonal antibody detecting Lrrk2. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Mouse LRRK2/Dardarin (Ile2151-Leu2500).
Target EC:2.7.11.1, EC:3.6.5.-, Leucine-rich repeat serine/threonine-protein kinase 2, Lrrk2
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Purified by antigen affinity column.
Accession Q5S006
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2/Dardarin) is a ~284 kDa protein. Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, innate immunity, autophagy, and vesicle trafficking. Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation. Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB29, RAB35, and RAB43. Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A. Inhibits the interaction between RAB8A and GDI1 and/or GDI2 by phosphorylating 'Thr-72' on RAB8A.

1. Steger, M. et al. (2016) eLife 5. PMID: 26824392
2. Chen, ZC. et al. (2017) Science signaling 10. PMID: 28720718
3. Steger, M. et al. (2017) eLife 6. PMID: 29125462
4. Purlyte, E. et al. (2018) The EMBO journal 37, 1-18. PMID: 29212815
5. Dhekne, HS. et al. (2018) eLife 7. PMID: 30398148
6. Cho, HJ. et al. (2014) The EMBO journal 33, 2314-31. PMID: 25201882
7. Eguchi, T. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, E9115-E9124. PMID: 30209220
Note For research use only
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Formula
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Anti-Mouse LRRK2/Dardarin Polyclonal Antibody

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