Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

Name: Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody
Brand: abinScience
SKU: MA497014
Price: 96 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

MA497014

설명

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014) is a rabbit polyclonal antibody detecting MAG/Myelin-associated glycoprotein in ELISA, IHC, WB. Suitable for Rattus norvegicus, Human, and Mus musculus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse MAG/Myelin-associated glycoprotein (Asp235-Glu410).

타겟

MAG/Myelin-associated glycoprotein

정제

Purified by antigen affinity column.

등록번호

P20917

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

대체 이름

Myelin-associated glycoprotein, Siglec-4a, Mag

배경

Myelin-associated glycoprotein (MAG) is a ~69 kDa protein. Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth that inhibits axon longitudinal growth.

1. Liu, BP. et al. (2002) Science (New York, N.Y.) 297, 1190-3. PMID: 12089450

2. Pronker, MF. et al. (2016) Nature communications 7, 13584. PMID: 27922006

3. Kelm, S. et al. (1994) Current biology : CB 4, 965-72. PMID: 7533044

4. Schachner, M. et al. (2000) Glia 29, 154-65. PMID: 10625334

5. Li, C. et al. (1994) Nature 369, 747-50. PMID: 7516497

6. Bartsch, S. et al. (1997) Brain research 762, 231-4. PMID: 9262180

7. Li, C. et al. (1998) Journal of neuroscience research 51, 210-7. PMID: 9469574

8. Yin, X. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1953-62. PMID: 9482781

9. Fujita, N. et al. (1998) The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 1970-8. PMID: 9482783

10. Palandri, A. et al. (2015) Cell death & disease 6, e1876. PMID: 26335717

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse MAG/Myelin-associated glycoprotein Polyclonal Antibody (MA497014)

개요

이미지

참고 문헌

데이터시트

SDS