Anti-Mouse NNMT Polyclonal Antibody (MW468014)

Name: Anti-Mouse NNMT Polyclonal Antibody
Brand: abinScience
SKU: MW468014
Price: 168 USD
Availability: InStock

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100ug

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호

MW468014

설명

Anti-Mouse NNMT Polyclonal Antibody (MW468014) is a rabbit polyclonal antibody detecting Nnmt. Suitable for Mouse.

종 반응성

Mouse

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Mouse NNMT (Met1-Glu264).

타겟

EC:2.1.1.1, Nicotinamide N-methyltransferase, Nnmt

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

등록번호

O55239

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

배경

Nicotinamide N-methyltransferase (NNMT) is a ~29 kDa protein. Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis.

1. Hong, S. et al. (2015) Nature medicine 21, 887-94. PMID: 26168293

2. Kannt, A. et al. (2018) Scientific reports 8, 3660. PMID: 29483571

3. Kraus, D. et al. (2014) Nature 508, 258-62. PMID: 24717514

참고사항

For research use only

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참고 문헌

데이터시트

Anti-Mouse NNMT Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Mouse NNMT Polyclonal Antibody (MW468014)

개요

이미지

참고 문헌

데이터시트

SDS