Mouse NNMT Recombinant Protein (N-His) (MW468012)

Name: Mouse NNMT Recombinant Protein (N-His)
Brand: abinScience
SKU: MW468012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	MW468012
Description	Recombinant Mouse NNMT Protein, N-His (MW468012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	O55239
Protein length	Met1-Glu264
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	EC:2.1.1.1, Nicotinamide N-methyltransferase, Nnmt
Background	Nicotinamide N-methyltransferase is a ~29 kDa protein. Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. 1. Hong, S. et al. (2015) Nature medicine 21, 887-94. PMID: 26168293 2. Kannt, A. et al. (2018) Scientific reports 8, 3660. PMID: 29483571 3. Kraus, D. et al. (2014) Nature 508, 258-62. PMID: 24717514
Note	For research use only

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Datasheet

Mouse NNMT Recombinant Protein (N-His).pdf

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Mouse NNMT Recombinant Protein (N-His) (MW468012)

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