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Anti-Mouse NNMT Polyclonal Antibody (MW468014)

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Overview
Catalog No.MW468014
Description
Anti-Mouse NNMT Polyclonal Antibody (MW468014) is a rabbit polyclonal antibody detecting Nnmt. Suitable for Mouse.
Species reactivityMouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Mouse NNMT (Met1-Glu264).
Target EC:2.1.1.1, Nicotinamide N-methyltransferase, Nnmt
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O55239
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Nicotinamide N-methyltransferase (NNMT) is a ~29 kDa protein. Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis.

1. Hong, S. et al. (2015) Nature medicine 21, 887-94. PMID: 26168293
2. Kannt, A. et al. (2018) Scientific reports 8, 3660. PMID: 29483571
3. Kraus, D. et al. (2014) Nature 508, 258-62. PMID: 24717514
Note For research use only
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Formula
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Anti-Mouse NNMT Polyclonal Antibody

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