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| 카탈로그 번호 | MC513107 |
|---|---|
| 종 반응성 | Human, Mouse |
| 응용 분야 | ELISA, FCM |
| 숙주 종 | Rat |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | 59R1 |
| 타겟 | N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2, Neurogenic locus notch homolog protein 3, NOTCH3, Notch 3 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | O35516, Q61982 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| 배경 | Neurogenic locus notch homolog protein 2 (NOTCH2/NOTCH3) is a ~265 kDa protein. Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. 1. Hamada, Y. et al. (1999) Development (Cambridge, England) 126, 3415-24. PMID: 10393120 2. Fukushima, H. et al. (2008) Molecular and cellular biology 28, 6402-12. PMID: 18710934 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Mouse NOTCH2/3 Antibody (59R1)
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