

| 카탈로그 번호 | MX160014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse OSTN Polyclonal Antibody (MX160014) is a rabbit polyclonal antibody detecting OSTN in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse OSTN (Phe26-Gly130). | ||||||||
| 타겟 | OSTN, Osteocrin, Musclin | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P61364 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Osteocrin (OSTN) is a ~14 kDa protein. Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C. May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle. 1. Thomas, G. et al. (2003) The Journal of biological chemistry 278, 50563-71. PMID: 14523025 2. Moffatt, P. et al. (2007) The Journal of biological chemistry 282, 36454-62. PMID: 17951249 3. Subbotina, E. et al. (2015) Proceedings of the National Academy of Sciences of the United States of America 112, 16042-7. PMID: 26668395 4. Nishizawa, H. et al. (2004) The Journal of biological chemistry 279, 19391-5. PMID: 15044443 | ||||||||
| 참고사항 | For research use only. |
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