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| 카탈로그 번호 | MS826137 |
|---|---|
| 종 반응성 | Human, Mouse |
| 응용 분야 | ELISA, FCM |
| 숙주 종 | Rat |
| 클론성 | Monoclonal |
| 이소타입 | IgG1, kappa |
| 클론 ID | 6D7 |
| 접합 | APC |
| 타겟 | ShhNC, Sonic hedgehog protein, Shh N-terminal processed signaling domains, SHH, Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains, ShhN, ShhNp, HHG-1 |
| 내독소 수준 | Please contact with the lab for this information. |
| 관련 제품 | Rat IgG1, kappa Recombinant Isotype Control Antibody (ES26-14D1.11), APC |
| 등록번호 | Q62226 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| 배경 | Sonic hedgehog protein (SHH) is a ~47 kDa protein. The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN. Both activities occur in the reticulum endoplasmic. Once cleaved, ShhC is degraded in the endoplasmic reticulum. 1. Roelink, H. et al. (1995) Cell 81, 445-55. PMID: 7736596 2. Bumcrot, DA. et al. (1995) Molecular and cellular biology 15, 2294-303. PMID: 7891723 3. Porter, JA. et al. (1996) Science (New York, N.Y.) 274, 255-9. PMID: 8824192 4. Chen, X. et al. (2011) The Journal of cell biology 192, 825-38. PMID: 21357747 |
| 참고사항 | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |
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