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| 카탈로그 번호 | MW708013 | ||||||
|---|---|---|---|---|---|---|---|
| 종 반응성 | Human, Mouse | ||||||
| 응용 분야 | ELISA, IP, WB | ||||||
| 숙주 종 | Rat | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | IgG1, kappa | ||||||
| 클론 ID | SAA0274 | ||||||
| 타겟 | Signal transducer and activator of transcription 3, APRF, STAT3, Acute-phase response factor | ||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | P42227 | ||||||
| RRID | Anti-Mouse STAT3 Antibody (SAA0274) (abinScience Cat# MW708013, RRID:AB_3725645) |
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| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 배경 | Signal transducer and activator of transcription 3 (STAT3) is a ~88 kDa protein. Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. 1. Ren, F. et al. (2013) Cellular signalling 25, 2272-80. PMID: 23917203 2. Ren, F. et al. (2015) FEBS letters 589, 1890-6. PMID: 26026268 3. Bates, SH. et al. (2003) Nature 421, 856-9. PMID: 12594516 4. Gonzalez, RR. et al. (2006) The Journal of biological chemistry 281, 26320-8. PMID: 16825198 5. Kostromina, E. et al. (2010) Endocrinology 151, 2050-9. PMID: 20215569 6. Manukyan, I. et al. (2010) Journal of cellular and molecular medicine 14, 1707-16. PMID: 19538478 7. Choi, SM. et al. (2013) The Journal of experimental medicine 210, 551-61. PMID: 23401489 | ||||||
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Mouse STAT3 Antibody (SAA0274)
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