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| 카탈로그 번호 | MP967014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Mouse TREML4 Polyclonal Antibody (MP967014) is a rabbit polyclonal antibody detecting TREML4 in ELISA, IHC, WB. Suitable for Mouse.
Highlights
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| 종 반응성 | Mouse | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Mouse TREML4 (Val31-Pro138). | ||||||||
| 타겟 | Trem-like transcript 4 protein (TLT-4) (Triggering receptor expressed on myeloid cells-like protein 3) (Triggering receptor expressed on myeloid cells-like protein 4) | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | Q3LRV9 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Trem-like transcript 4 protein (TREML4) is a ~29 kDa protein. Positively regulates Toll-like receptor signaling via TLR7, TLR9 and TLR13 in neutrophils and splenic macrophages. Regulates TLR7 signaling by controlling ligand-induced recruitment of TLR7 from the endoplasmic reticulum to endosomes and lysosomes. Positively regulates Toll-like receptor TLR9-induced production of inflammatory cytokines but is dispensable for IFNB1 production. Involved in the anti-viral response to several viruses including influenza virus, vesicular stomatitis virus and cytomegalovirus. Binds to late apoptotic, and necrotic cells, but not living or early apoptotic cells, but is not essential for uptake of dying cells by dendritic cells (DCs). 1. Ramirez-Ortiz, ZG. et al. (2015) Nature immunology 16, 495-504. PMID: 25848864 2. Hemmi, H. et al. (2009) Journal of immunology (Baltimore, Md. : 1950) 182, 1278-86. PMID: 19155473 3. Hemmi, H. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 188, 1147-55. PMID: 22210914 | ||||||||
| 참고사항 | For research use only. |
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