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| 카탈로그 번호 | MP297015 |
|---|---|
| 설명 |
Anti-Mouse WDR45 Monoclonal Antibody (1A445) [1A445] (MP297015) is a mouse monoclonal antibody detecting Wdr45 in ELISA, WB. Suitable for Mouse.
Highlights
|
| 종 반응성 | Mouse |
| 응용 분야 | ELISA, WB |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2b |
| 클론 ID | 1A445 |
| 면역원 | Recombinant Mouse WDR45 protein. |
| 타겟 | WD repeat domain phosphoinositide-interacting protein 4, WIPI-4, WD repeat domain X-linked 1, WD repeat-containing protein 45, Wdr45, DXImx38e, Wdrx1, Wipi4 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | Q91VM3 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | WD repeat domain phosphoinositide-interacting protein 4 (WDR45) is a ~39 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P). Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes. Probably recruited to membranes through its PtdIns3P activity. 1. Saitsu, H. et al. (2013) Nature genetics 45, 445-9, 449e1. PMID: 23435086 2. Bakula, D. et al. (2017) Nature communications 8, 15637. PMID: 28561066 3. Maeda, S. et al. (2019) eLife 8. PMID: 31271352 |
| 참고사항 | For research use only. |
SDS-PAGE for Anti-Mouse WDR45 Monoclonal Antibody (1A445)
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