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| 카탈로그 번호 | HW585053 | ||||||
|---|---|---|---|---|---|---|---|
| 종 반응성 | Human | ||||||
| 응용 분야 | ELISA, WB | ||||||
| 숙주 종 | Human | ||||||
| 클론성 | Monoclonal | ||||||
| 이소타입 | VHH-Fc | ||||||
| 클론 ID | SAA2317 | ||||||
| 타겟 | Sodium channel protein type 4 subunit alpha, SkM1, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, SCN4A, Sodium channel protein type 5 subunit alpha, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5, hH1, SCN5A | ||||||
| 내독소 수준 | Please contact with the lab for this information. | ||||||
| 순도 | >95% as determined by SDS-PAGE. | ||||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||||
| 등록번호 | P35499, Q14524 | ||||||
| 형태 | Liquid | ||||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||
| 배경 | Sodium channel protein type 4 subunit alpha (Nav1.4,Nav1.5) is a ~208 kDa protein. Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction. 1. Tsujino, A. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 7377-82. PMID: 12766226 2. Dice, MS. et al. (2004) Muscle & nerve 30, 277-88. PMID: 15318338 3. Carle, T. et al. (2006) Biochemical and biophysical research communications 348, 653-61. PMID: 16890191 4. Webb, J. et al. (2008) Neurology 70, 755-61. PMID: 17898326 5. Groome, JR. et al. (2008) Channels (Austin, Tex.) 2, 39-50. PMID: 18690054 6. Kubota, T. et al. (2009) Muscle & nerve 39, 666-73. PMID: 19347921 7. Arnold, WD. et al. (2015) Annals of neurology 77, 840-50. PMID: 25707578 8. Habbout, K. et al. (2016) Neurology 86, 161-9. PMID: 26659129 9. Zaharieva, IT. et al. (2016) Brain : a journal of neurology 139, 674-91. PMID: 26700687 10. Baroni, D. et al. (2018) Human mutation 39, 1402-1415. PMID: 29992740 | ||||||
| 참고사항 | For research use only |
SDS-PAGE for Anti-Nav1.4/Nav1.5 Na+ channel Antibody (SAA2317)
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