Anti-Nav1.4/Nav1.5 Na+ channel Recombinant Antibody (SAA2316) (HW585043)

Name: Anti-Nav1.4/Nav1.5 Na+ channel Recombinant Antibody (SAA2316)
Brand: abinScience
SKU: HW585043
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HW585043

Species reactivity

Human

Applications

ELISA, WB

Host species

Human

Isotype

VHH-Fc

Clone ID

SAA2316

Clonality

Monoclonal

Target

Sodium channel protein type 4 subunit alpha, SkM1, Sodium channel protein skeletal muscle subunit alpha, Sodium channel protein type IV subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.4, SCN4A, Sodium channel protein type 5 subunit alpha, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5, hH1, SCN5A

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P35499, Q14524

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sodium channel protein type 4 subunit alpha (Nav1.4,Nav1.5) is a ~208 kDa protein. Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction.

1. Tsujino, A. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 7377-82. PMID: 12766226

2. Dice, MS. et al. (2004) Muscle & nerve 30, 277-88. PMID: 15318338

3. Carle, T. et al. (2006) Biochemical and biophysical research communications 348, 653-61. PMID: 16890191

4. Webb, J. et al. (2008) Neurology 70, 755-61. PMID: 17898326

5. Groome, JR. et al. (2008) Channels (Austin, Tex.) 2, 39-50. PMID: 18690054

6. Kubota, T. et al. (2009) Muscle & nerve 39, 666-73. PMID: 19347921

7. Arnold, WD. et al. (2015) Annals of neurology 77, 840-50. PMID: 25707578

8. Habbout, K. et al. (2016) Neurology 86, 161-9. PMID: 26659129

9. Zaharieva, IT. et al. (2016) Brain : a journal of neurology 139, 674-91. PMID: 26700687

10. Baroni, D. et al. (2018) Human mutation 39, 1402-1415. PMID: 29992740

Note

For research use only

Images

SDS-PAGE

SDS-PAGE for Anti-Nav1.4/Nav1.5 Na+ channel Antibody (SAA2316)

References

Datasheet

Anti-Nav1.4/Nav1.5 Na+ channel Recombinant Antibody (SAA2316).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Nav1.4/Nav1.5 Na+ channel Recombinant Antibody (SAA2316) (HW585043)

Overview

Images

References

Datasheet

SDS

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