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| 카탈로그 번호 | JN971014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-Neisseria meningitidis NadA Polyclonal Antibody (JN971014) is a rabbit polyclonal antibody detecting autotransporter adhesin NadA in ELISA, IHC, WB.
Highlights
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| 종 반응성 | Neisseria meningitidis | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Neisseria meningitidis NadA (Ala39-Ala170). | ||||||||
| 타겟 | autotransporter adhesin NadA, partial, autotransporter adhesin NadA, partial | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P0DV44 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Neisseria adhesin A (NadA) is a ~42 kDa protein. Adheres to and induces bacterial uptake by human epithelial cells in a microfilament-dependent process. Binding is reduced by pronase treatment, suggesting there is a protein receptor on the human cells. Possible human protein receptors include integrin beta-1 (ITGB1) and oxidized low-density lipoprotein receptor 1 (OLR1) (Probable). Binds to extracellular human Hsp90 (preferentially the beta isoform, HSP90AB1) on monocytes, binding stimulates monocytes in a TLR4-dependent fashion, polymixin B, which binds NadA, blocks the activation. Hsp90 is probably not the first receptor on human monocytes. 1. Capecchi, B. et al. (2005) Molecular microbiology 55, 687-98. PMID: 15660996 2. Liguori, A. et al. (2018) mBio 9. PMID: 30327444 3. Cecchini, P. et al. (2011) PloS one 6, e25089. PMID: 21949862 4. Bozza, G. et al. (2014) PloS one 9, e110047. PMID: 25347845 5. Comanducci, M. et al. (2002) The Journal of experimental medicine 195, 1445-54. PMID: 12045242 | ||||||||
| 참고사항 | For research use only. |
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