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| 카탈로그 번호 | HW468014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-NNMT Polyclonal Antibody (HW468014) is a rabbit polyclonal antibody detecting NNMT in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 종 반응성 | Human | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human NNMT (Met1-Arg258). | ||||||||
| 타겟 | Nicotinamide N-methyltransferase, NNMT | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P40261 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Nicotinamide N-methyltransferase (NNMT) is a ~29 kDa protein. Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway. Plays a central role in regulating cellular methylation potential, by consuming S-adenosyl-L-methionine and limiting its availability for other methyltransferases. Actively mediates genome-wide epigenetic and transcriptional changes through hypomethylation of repressive chromatin marks, such as H3K27me3. In a developmental context, contributes to low levels of the repressive histone marks that characterize pluripotent embryonic stem cell pre-implantation state. Acts as a metabolic regulator primarily on white adipose tissue energy expenditure as well as hepatic gluconeogenesis and cholesterol biosynthesis. 1. Peng, Y. et al. (2011) Biochemistry 50, 7800-8. PMID: 21823666 2. Ulanovskaya, OA. et al. (2013) Nature chemical biology 9, 300-6. PMID: 23455543 3. Aksoy, S. et al. (1994) The Journal of biological chemistry 269, 14835-40. PMID: 8182091 4. Sperber, H. et al. (2015) Nature cell biology 17, 1523-35. PMID: 26571212 5. Eckert, MA. et al. (2019) Nature 569, 723-728. PMID: 31043742 6. Nemmara, VV. et al. (2018) ACS chemical biology 13, 2663-2672. PMID: 30044909 | ||||||||
| 참고사항 | For research use only. |
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