Anti-RAB5A Polyclonal Antibody (HB244014)

Name: Anti-RAB5A Polyclonal Antibody
Brand: abinScience
SKU: HB244014
Price: 168 USD
Availability: InStock

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개요
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SDS

개요

카탈로그 번호

HB244014

설명

Anti-RAB5A Polyclonal Antibody (HB244014) is a rabbit polyclonal antibody detecting RAB5A in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human, Mouse, Rat

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human RAB5A (Asp136-Asn215).

타겟

Ras-related protein Rab-5A, RAB5A, RAB5

정제

Purified by antigen affinity column.

등록번호

P20339

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Ras-related protein Rab-5A (RAB5A) is a ~23 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes and involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Recruits FERRY complex to early endosomes, where FERRY links early endosomes with a subgroup of mRNAs to enable mRNA intracellular distribution.

1. Hoffenberg, S. et al. (2000) The Journal of biological chemistry 275, 24661-9. PMID: 10818110

2. Fouraux, MA. et al. (2004) Molecular biology of the cell 15, 611-24. PMID: 14617813

3. Zhu, G. et al. (2004) Nature structural & molecular biology 11, 975-83. PMID: 15378032

4. Haas, AK. et al. (2005) Nature cell biology 7, 887-93. PMID: 16086013

5. Hunker, CM. et al. (2006) Biochemical and biophysical research communications 340, 967-75. PMID: 16410077

6. Fuchs, E. et al. (2007) The Journal of cell biology 177, 1133-43. PMID: 17562788

7. Quentin, D. et al. (2023) Molecular cell 83, 1856-1871.e9. PMID: 37267906

8. Gauthier-Campbell, C. et al. (2004) Molecular biology of the cell 15, 2205-17. PMID: 14978216

9. Baietti, MF. et al. (2012) Nature cell biology 14, 677-85. PMID: 22660413

참고사항

For research use only.

이미지

참고 문헌

데이터시트

Anti-RAB5A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-RAB5A Polyclonal Antibody (HB244014)

개요

이미지

참고 문헌

데이터시트

SDS

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