Anti-Human TrkB Polyclonal Antibody (HS892014)

Name: Anti-Human TrkB Polyclonal Antibody
Brand: abinScience
SKU: HS892014
Price: 168 USD
Availability: InStock

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개요
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개요

카탈로그 번호

HS892014

설명

Anti-TrkB /NTRK2 Polyclonal Antibody (HS892014) is a rabbit polyclonal antibody detecting NTRK2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human TrkB /NTRK2 (Cys32-His430).

타겟

Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB, TRKB, NTRK2, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor, Trk-B

정제

Purified by antigen affinity column.

등록번호

Q16620

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

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제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

BDNF/NT-3 growth factors receptor (TrkB/NTRK2) is a ~91 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades.

1. Yeo, GS. et al. (2004) Nature neuroscience 7, 1187-9. PMID: 15494731

2. Haniu, M. et al. (1995) Archives of biochemistry and biophysics 322, 256-64. PMID: 7574684

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-Human TrkB Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Human TrkB Polyclonal Antibody (HS892014)

개요

이미지

참고 문헌

데이터시트

SDS

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