Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody (ZY332014)

Name: Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody
Brand: abinScience
SKU: ZY332014
Price: 168 USD
Availability: InStock

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개요
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참고 문헌
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SDS

개요

카탈로그 번호

ZY332014

설명

Anti-Tupaia chinensis CD107a/LAMP1 Polyclonal Antibody (ZY332014) is a rabbit polyclonal antibody detecting lysosome-associated membrane glycoprotein 1; LAMP1 in ELISA, IHC, WB. Suitable for Tupaia chinensis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Tupaia chinensis (Chinese tree shrew)

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant tupaia chinensis CD107a/LAMP1 (Met136-Met484).

타겟

lysosome-associated membrane glycoprotein 1; LAMP1

내독소 수준

Please contact with the lab for this information.

정제

Purified by antigen affinity column.

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Lysosome-associated membrane glycoprotein 1 (CD107a/LAMP1) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content.

1. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818

2. Peters, PJ. et al. (1991) The Journal of experimental medicine 173, 1099-109. PMID: 2022921

3. Krzewski, K. et al. (2013) Blood 121, 4672-83. PMID: 23632890

4. Cohnen, A. et al. (2013) Blood 122, 1411-8. PMID: 23847195

5. Sawada, R. et al. (1993) The Journal of biological chemistry 268, 12675-81. PMID: 7685349

참고사항

For research use only

이미지

참고 문헌

데이터시트

Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-Tupaia chinensis LAMP-1/CD107a Polyclonal Antibody (ZY332014)

개요

이미지

참고 문헌

데이터시트

SDS