Anti-UBA7 Polyclonal Antibody (HW373014)

Name: Anti-UBA7 Polyclonal Antibody
Brand: abinScience
SKU: HW373014
Price: 168 USD
Availability: InStock

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100ug

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개요
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개요

카탈로그 번호

HW373014

설명

Anti-UBA7 Polyclonal Antibody (HW373014) is a rabbit polyclonal antibody detecting UBA7 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

종 반응성

Human

응용 분야

ELISA, IHC, WB

숙주 종

Rabbit

클론성

Polyclonal

이소타입

IgG

면역원

E. coli - derived recombinant Human UBA7 (Lys429-Val488).

타겟

D8, Ubiquitin-activating enzyme 7, UBE1L, UBA7, Ubiquitin-like modifier-activating enzyme 7, UBE2, Ubiquitin-activating enzyme E1 homolog

정제

Purified by antigen affinity column.

등록번호

P41226

형태

Liquid

저장 완충액

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.

제품 사용 정보

응용 분야	희석
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

안정성 및 저장

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

배경

Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a ~111 kDa protein. E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling.

1. Park, JH. et al. (2016) Nature communications 7, 12513. PMID: 27545325

2. Lenschow, DJ. et al. (2005) Journal of virology 79, 13974-83. PMID: 16254333

3. Giannakopoulos, NV. et al. (2009) Journal of virology 83, 1602-10. PMID: 19073728

4. Zhao, P. et al. (2017) Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 56, 44-53. PMID: 29056542

5. Lee, MK. et al. (2018) Journal of virology 92. PMID: 29743376

6. Sarkar, R. et al. (2023) Cellular signalling 112, 110891. PMID: 37722521

7. Zhao, C. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 2253-8. PMID: 20133869

8. Kim, YJ. et al. (2016) PLoS pathogens 12, e1005850. PMID: 27564865

참고사항

For research use only.

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참고 문헌

데이터시트

Anti-UBA7 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

항체

어세이 키트

Anti-UBA7 Polyclonal Antibody (HW373014)

개요

이미지

참고 문헌

데이터시트

SDS