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| 카탈로그 번호 | HY589014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 설명 |
Anti-UCHL1 Polyclonal Antibody (HY589014) is a rabbit polyclonal antibody detecting UCHL1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.
Highlights
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| 종 반응성 | Human, Mouse, Rat | ||||||||
| 응용 분야 | ELISA, IHC, WB | ||||||||
| 숙주 종 | Rabbit | ||||||||
| 클론성 | Polyclonal | ||||||||
| 이소타입 | IgG | ||||||||
| 면역원 | E. coli - derived recombinant Human UCHL1 (Gln2-Ala223). | ||||||||
| 타겟 | UCH-L1, PGP 9.5, UCHL1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP9.5 | ||||||||
| 정제 | Purified by antigen affinity column. | ||||||||
| 등록번호 | P09936 | ||||||||
| 형태 | Liquid | ||||||||
| 저장 완충액 | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 배경 | Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a ~24 kDa protein. Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis. Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1. In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways. Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production. Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes. 1. Zhang, M. et al. (2012) Journal of neurochemistry 120, 1129-38. PMID: 22212137 2. Bilguvar, K. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 3489-94. PMID: 23359680 3. Goto, Y. et al. (2015) Nature communications 6, 6153. PMID: 25615526 4. Liu, Y. et al. (2002) Cell 111, 209-18. PMID: 12408865 5. Larsen, CN. et al. (1996) Biochemistry 35, 6735-44. PMID: 8639624 6. Leroy, E. et al. (1998) Nature 395, 451-2. PMID: 9774100 | ||||||||
| 참고사항 | For research use only. |
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