InVivoMAb Anti-Human Angiopoietin-like Protein 3/ANGPTL3 Antibody (Iv0160) (HV176010)

Name: InVivoMAb Anti-Human Angiopoietin-like Protein 3/ANGPTL3 Antibody (Iv0160)
Brand: abinScience
SKU: HV176010
Price: 370 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HV176010
설명	InVivoMAb Anti-Human ANGPTL3 Antibody (Iv0160) [Iv0160] (HV176010) is a human monoclonal antibody detecting ANG-5 in ELISA, Neutralization. Suitable for Human, Mouse, and Rat. Highlights ●Multi-Species — Cross-reactive for translational research.
종 반응성	Human, Mouse, Rat
응용 분야	ELISA, Neutralization
숙주 종	Human
클론성	Monoclonal
이소타입	IgG4, kappa
클론 ID	Iv0160
타겟	ANG-5, Angiopoietin-like protein 3, ANGPT5, Angiopoietin-5, ANGPTL3, Angiopoietin-related protein 3
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
관련 제품	pH 7.4 Dilution Buffer
정제	Protein A/G purified from cell culture supernatant.
등록번호	Q9Y5C1
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Angiopoietin-related protein 3 (ANGPTL3) is a ~53 kDa protein. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. 1. Koishi, R. et al. (2002) Nature genetics 30, 151-7. PMID: 11788823 2. Ono, M. et al. (2003) The Journal of biological chemistry 278, 41804-9. PMID: 12909640 3. Robciuc, MR. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 1706-13. PMID: 23661675 4. Tikka, A. et al. (2014) Bioscience reports 34, e00160. PMID: 25495645 5. Shimizugawa, T. et al. (2002) The Journal of biological chemistry 277, 33742-8. PMID: 12097324 6. Lee, EC. et al. (2009) The Journal of biological chemistry 284, 13735-13745. PMID: 19318355 7. Liu, J. et al. (2010) The Journal of biological chemistry 285, 27561-70. PMID: 20581395 8. Shimamura, M. et al. (2007) Arteriosclerosis, thrombosis, and vascular biology 27, 366-72. PMID: 17110602 9. Shan, L. et al. (2009) The Journal of biological chemistry 284, 1419-24. PMID: 19028676 10. Shimamura, M. et al. (2003) Biochemical and biophysical research communications 301, 604-9. PMID: 12565906
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)