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| 카탈로그 번호 | HW601010 | ||||
|---|---|---|---|---|---|
| 설명 |
InVivoMAb Anti-Human CD110/TPOR Antibody (3D9) [3D9] (HW601010) is a human monoclonal antibody detecting TPO-R in Agonist, ELISA. Suitable for Human.
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| 종 반응성 | Human | ||||
| 응용 분야 | Agonist, ELISA | ||||
| 숙주 종 | Human | ||||
| 클론성 | Monoclonal | ||||
| 이소타입 | IgG1 | ||||
| 클론 ID | 3D9 | ||||
| 타겟 | TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110 | ||||
| 내독소 수준 | Please contact with the lab for this information. | ||||
| 순도 | >95% as determined by SDS-PAGE. | ||||
| 관련 제품 | pH 7.4 Dilution Buffer | ||||
| 정제 | Protein A/G purified from cell culture supernatant. | ||||
| 등록번호 | P40238 | ||||
| 형태 | Liquid | ||||
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
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| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. | ||||
| 제품 사용 정보 |
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| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 배경 | Thrombopoietin receptor (CD110/TPOR) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. 1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890 2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268 | ||||
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-Human CD110/TPOR Antibody (3D9)
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