InVivoMAb Anti-Human alpha-Synuclein Antibody (9E4#) (HW755050)

Name: InVivoMAb Anti-Human alpha-Synuclein Antibody (9E4#)
Brand: abinScience
SKU: HW755050
Price: 370 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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사양:

100ug
1mg

수량:

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개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HW755050
설명	InVivoMAb Anti-Human SNCA Antibody (9E4#) [9E4#] (HW755050) is a human monoclonal antibody detecting SNCA in ELISA, Neutralization. Suitable for Human.
종 반응성	Human
응용 분야	ELISA, Neutralization
숙주 종	Human
클론성	Monoclonal
이소타입	IgG1, kappa
클론 ID	9E4#
타겟	SNCA
내독소 수준	Please contact with the lab for this information.
순도	>95% as determined by SDS-PAGE.
관련 제품	pH 7.4 Dilution Buffer
정제	Protein A/G purified from cell culture supernatant.
등록번호	P37840
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. 1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282 2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590 3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128 4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (HyHEL-10) (HV080407) Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)