InVivoMAb Anti-Mouse CCR8 Antibody (Iv0265) (MW444020)

Name: InVivoMAb Anti-Mouse CCR8 Antibody (Iv0265)
Brand: abinScience
SKU: MW444020
Price: 370 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

100ug
1mg

수량:

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	MW444020
설명	InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265) [Iv0265] (MW444020) is a mouse monoclonal antibody detecting C-C chemokine receptor type 8 in ELISA, FCM, Neutralization. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
종 반응성	Mouse
응용 분야	ELISA, FCM, Neutralization
숙주 종	Mouse
클론성	Monoclonal
이소타입	IgG2a, lambda
클론 ID	Iv0265
타겟	C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1
내독소 수준	Please contact with the lab for this information.
순도	>95% by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P56484
형태	Liquid
저장 완충액	0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production. 1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461 2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588 3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)