中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | MB978010 |
|---|---|
| 설명 |
InVivoMAb Anti-Mouse IL11 Antibody (Iv0284) [Iv0284] (MB978010) is a mouse monoclonal antibody detecting Interleukin-11 in ELISA, FCM, Neutralization, WB, in vivo research. Suitable for Mouse.
Highlights
|
| 종 반응성 | Mouse |
| 응용 분야 | ELISA, FCM, Neutralization, WB, in vivo research |
| 숙주 종 | Mouse |
| 클론성 | Monoclonal |
| 이소타입 | IgG2a, kappa |
| 클론 ID | Iv0284 |
| 타겟 | Interleukin-11, IL-11, Il11 |
| 내독소 수준 | < 10 EU/mg |
| 순도 | >95% as determined by SDS-PAGE. |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P47873 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Morris, JC. et al. (1996) Experimental hematology 24, 1369-76. PMID: 8913282 2. Nishina, T. et al. (2012) Science signaling 5, ra5. PMID: 22253262 3. Barton, VA. et al. (1999) The Journal of biological chemistry 274, 5755-61. PMID: 10026196 4. Putoczki, TL. et al. (2013) Cancer cell 24, 257-71. PMID: 23948300 |
| 참고사항 | For research use only. |
| Isotype Control | Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023) |
SDS-PAGE for InVivoMAb Anti-Mouse IL11 Antibody (Iv0284)
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
