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| 카탈로그 번호 | VK557010 |
|---|---|
| 설명 |
InVivoMAb Anti-Poliovirus Capsid protein VP1 (C3) [C3] (VK557010) is a human monoclonal antibody detecting Genome polyprotein in ELISA, Neutralization.
|
| 종 반응성 | Poliovirus type 1 (PV1) |
| 응용 분야 | ELISA, Neutralization |
| 숙주 종 | Human |
| 클론성 | Monoclonal |
| 이소타입 | IgG4, kappa |
| 클론 ID | C3 |
| 타겟 | Genome polyprotein, Capsid protein VP1, Virion protein 1 |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >95% as determined by SDS-PAGE. |
| 관련 제품 | pH 7.4 Dilution Buffer |
| 정제 | Protein A/G purified from cell culture supernatant. |
| 등록번호 | P03300 |
| 형태 | Liquid |
| 저장 완충액 | 0.01M PBS pH 7.4 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 배경 | Genome polyprotein (Capsid protein VP1) is a ~246 kDa protein. Forms an icosahedral capsid of pseudo T=3 symmetry with capsid proteins VP2 and VP3. The capsid is 300 Angstroms in diameter, composed of 60 copies of each capsid protein and enclosing the viral positive strand RNA genome. Capsid protein VP1 mainly forms the vertices of the capsid. Capsid protein VP1 interacts with host cell receptor PVR to provide virion attachment to target host epithelial cells. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis in Hela cells and through caveolin-mediated endocytosis in brain microvascular endothelial cells. 1. Hogle, JM. et al. (1985) Science (New York, N.Y.) 229, 1358-65. PMID: 2994218 2. Strauss, M. et al. (2013) Journal of virology 87, 3903-14. PMID: 23365424 3. Strauss, M. et al. (2015) Journal of virology 89, 4143-57. PMID: 25631086 4. Brandenburg, B. et al. (2007) PLoS biology 5, e183. PMID: 17622193 5. Coyne, CB. et al. (2007) The EMBO journal 26, 4016-28. PMID: 17717529 6. Bergelson, JM. (2008) Trends in microbiology 16, 44-7. PMID: 18191571 |
| 참고사항 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for InVivoMAb Anti-Poliovirus Capsid protein VP1 (C3).
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