Human CAPRIN1 Recombinant Protein (N-His) (HC541022)

Name: Human CAPRIN1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC541022
Price: 211 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

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50ug
100ug
1mg

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개요
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참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HC541022
설명	Recombinant Human CAPRIN1 Protein, N-His (HC541022) expressed in E. coli, spanning Arg132-His252. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
발현 시스템	E. coli
등록번호	Q14444
단백질 길이	Arg132-His252
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
예측 분자량	16.66 kDa
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	CAPRIN1, Caprin-1, Cell cycle-associated protein 1, Cytoplasmic activation- and proliferation-associated protein 1, GPI-anchored membrane protein 1, GPI-anchored protein p137, GPI-p137, GPIAP1, GPIP137, M11S1, Membrane component chromosome 11 surface marker 1, RNA granule protein 105, RNG105, p137GPI
배경	Caprin-1 is a ~78 kDa protein. mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Plays an essential role in cytoplasmic stress granule formation. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. 1. Solomon, S. et al. (2007) Molecular and cellular biology 27, 2324-42. PMID: 17210633 2. Kim, TH. et al. (2019) Science (New York, N.Y.) 365, 825-829. PMID: 31439799 3. Pavinato, L. et al. (2023) Brain : a journal of neurology 146, 534-548. PMID: 35979925 4. Jia, X. et al. (2022) Science advances 8, eabo7112. PMID: 35977029 5. Sanders, DW. et al. (2020) Cell 181, 306-324.e28. PMID: 32302570 6. Yang, P. et al. (2020) Cell 181, 325-345.e28. PMID: 32302571 7. Guillén-Boixet, J. et al. (2020) Cell 181, 346-361.e17. PMID: 32302572 8. Kim, TH. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34074792 9. Toyama, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2210492119. PMID: 36040869
참고사항	For research use only