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| 카탈로그 번호 | HD226012 |
|---|---|
| 설명 |
Recombinant Human CUL7 Protein, N-His (HD226012) expressed in E. coli, spanning Met1-Ser317. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q14999 |
| 단백질 길이 | Met1-Ser317 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 37.36 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CUL-7, CUL7, Cullin-7, KIAA0076 |
| 배경 | Cullin-7 is a ~191 kDa protein. Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53. However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1. 1. Dias, DC. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16601-6. PMID: 12481031 2. Arai, T. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 9855-60. PMID: 12904573 3. Litterman, N. et al. (2011) PLoS biology 9, e1001060. PMID: 21572988 4. Hanson, D. et al. (2011) American journal of human genetics 89, 148-53. PMID: 21737058 5. Yan, J. et al. (2014) Molecular cell 54, 791-804. PMID: 24793695 6. Hopf, LVM. et al. (2022) Nature structural & molecular biology 29, 854-862. PMID: 35982156 |
| 참고사항 | For research use only |
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