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Anti-Human CUL7 Polyclonal Antibody (HD226014)

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Overview
Catalog No.HD226014
Description
Anti-Human CUL7 Polyclonal Antibody (HD226014) is a rabbit polyclonal antibody detecting CUL7. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human CUL7 (Met1-Ser317).
Target CUL-7, CUL7, Cullin-7, KIAA0076
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q14999
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Cullin-7 (CUL7) is a ~191 kDa protein. Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. The Cul7-RING(FBXW8) complex alone lacks ubiquitination activity and does not promote polyubiquitination and proteasomal degradation of p53/TP53. However it mediates recruitment of p53/TP53 for ubiquitination by neddylated CUL1-RBX1.

1. Dias, DC. et al. (2002) Proceedings of the National Academy of Sciences of the United States of America 99, 16601-6. PMID: 12481031
2. Arai, T. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 9855-60. PMID: 12904573
3. Litterman, N. et al. (2011) PLoS biology 9, e1001060. PMID: 21572988
4. Hanson, D. et al. (2011) American journal of human genetics 89, 148-53. PMID: 21737058
5. Yan, J. et al. (2014) Molecular cell 54, 791-804. PMID: 24793695
6. Hopf, LVM. et al. (2022) Nature structural & molecular biology 29, 854-862. PMID: 35982156
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human CUL7 Polyclonal Antibody

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