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| 카탈로그 번호 | HD149012 |
|---|---|
| 설명 |
Recombinant Human DXO Protein, N-His (HD149012) expressed in E. coli, spanning Thr31-Lys396. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O77932 |
| 단백질 길이 | Thr31-Lys396 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 43.94 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 5'-3' exoribonuclease DXO, DOM3L, DOM3Z, DXO, DeNADding enzyme DXO, Decapping and exoribonuclease protein, Dom-3 homolog Z, EC:3.1.13.-, EC:3.6.1.-, NAD-capped RNA hydrolase DXO, NG6 |
| 배경 | Decapping and exoribonuclease protein is a ~44 kDa protein. Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to environmental stress. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. 1. Jiao, X. et al. (2017) Cell 168, 1015-1027.e10. PMID: 28283058 2. Grudzien-Nogalska, E. et al. (2019) Nature chemical biology 15, 575-582. PMID: 31101919 3. Picard-Jean, F. et al. (2018) PloS one 13, e0193804. PMID: 29601584 4. Doamekpor, SK. et al. (2020) Nucleic acids research 48, 6136-6148. PMID: 32374864 |
| 참고사항 | For research use only |
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