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Anti-Human DXO Polyclonal Antibody (HD149014)

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Overview
Catalog No.HD149014
Description
Anti-Human DXO Polyclonal Antibody (HD149014) is a rabbit polyclonal antibody detecting DXO. Suitable for Human, Mouse, and Rat.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human DXO (Thr31-Lys396).
Target 5'-3' exoribonuclease DXO, DOM3L, DOM3Z, DXO, DeNADding enzyme DXO, Decapping and exoribonuclease protein, Dom-3 homolog Z, EC:3.1.13.-, EC:3.6.1.-, NAD-capped RNA hydrolase DXO, NG6
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O77932
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Decapping and exoribonuclease protein (DXO) is a ~44 kDa protein. Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to environmental stress. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation.

1. Jiao, X. et al. (2017) Cell 168, 1015-1027.e10. PMID: 28283058
2. Grudzien-Nogalska, E. et al. (2019) Nature chemical biology 15, 575-582. PMID: 31101919
3. Picard-Jean, F. et al. (2018) PloS one 13, e0193804. PMID: 29601584
4. Doamekpor, SK. et al. (2020) Nucleic acids research 48, 6136-6148. PMID: 32374864
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human DXO Polyclonal Antibody

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