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| 카탈로그 번호 | HD398012 |
|---|---|
| 설명 |
Recombinant Human FBXL3 Protein, N-His (HD398012) expressed in E. coli, spanning Gly37-Trp428. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q9UKT7 |
| 단백질 길이 | Gly37-Trp428 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 46.89 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | F-box and leucine-rich repeat protein 3A, F-box/LRR-repeat protein 3, F-box/LRR-repeat protein 3A, FBL3A, FBXL3, FBXL3A |
| 배경 | F-box/LRR-repeat protein 3 is a ~48 kDa protein. Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. 1. Busino, L. et al. (2007) Science (New York, N.Y.) 316, 900-4. PMID: 17463251 2. Yoo, SH. et al. (2013) Cell 152, 1091-105. PMID: 23452855 3. Scott, DC. et al. (2016) Cell 166, 1198-1214.e24. PMID: 27565346 |
| 참고사항 | For research use only |
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