中文
English
한국어
日本語
Español
Français
Русский
| 카탈로그 번호 | HT027012 |
|---|---|
| 설명 |
Recombinant Human GluN2D/NR2D Protein, N-His (HT027012) expressed in E. coli, spanning Arg49-Tyr413. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | O15399 |
| 단백질 길이 | Arg49-Tyr413 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 41.37 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EB11, GRIN2D, GluN2D, Glutamate [NMDA] receptor subunit epsilon-4, Glutamate receptor ionotropic, NMDA 2D, N-methyl D-aspartate receptor subtype 2D, NMDAR2D, NR2D |
| 배경 | Glutamate receptor ionotropic, NMDA 2D is a ~143 kDa protein. Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+). Participates in synaptic plasticity for learning and memory formation. Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium. Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators. 1. Hackos, DH. et al. (2016) Neuron 89, 983-99. PMID: 26875626 2. Li, D. et al. (2016) American journal of human genetics 99, 802-816. PMID: 27616483 3. Chen, W. et al. (2017) Molecular pharmacology 91, 317-330. PMID: 28126851 4. Hess, SD. et al. (1998) Journal of neurochemistry 70, 1269-79. PMID: 9489750 5. Ogden, KK. et al. (2017) PLoS genetics 13, e1006536. PMID: 28095420 |
| 참고사항 | For research use only |
+86-027-65523339
중국 우한시 심둔사로 666번지 C동, 우한, 430206
