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| 카탈로그 번호 | HA200022 |
|---|---|
| 설명 |
Recombinant Human HDGFL2 Protein, N-GST & C-His (HA200022) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q7Z4V5 |
| 단백질 길이 | Met1-Asn87 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | HDGF-2, HDGF-related protein 2, HDGF2, HDGFL2, HDGFRP2, HRP-2, HRP2, Hepatoma-derived growth factor 2, Hepatoma-derived growth factor-related protein 2 |
| 배경 | Hepatoma-derived growth factor-related protein 2 is a ~74 kDa protein. Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression. 1. Zhu, X. et al. (2020) Nucleic acids research 48, 6563-6582. PMID: 32459350 2. Baude, A. et al. (2016) Nucleic acids research 44, 2214-26. PMID: 26721387 3. Gao, K. et al. (2015) Biochemical and biophysical research communications 458, 849-55. PMID: 25689719 |
| 참고사항 | For research use only |
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