Anti-Human HDGFL2 Recombinant Nanobody (SAA2783) (HA200013)

Name: Anti-Human HDGFL2 Recombinant Nanobody (SAA2783)
Brand: abinScience
SKU: HA200013
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HA200013
Description	Anti-Human HDGFL2 Nanobody (SAA2783) (HA200013) is a alpaca monoclonal antibody detecting HDGFL2. Suitable for Human.
Species reactivity	Human
Applications	ELISA
Host species	Alpaca
Isotype	VHH-His
Clone ID	SAA2783
Clonality	Monoclonal
Target	HDGF-2, HDGF-related protein 2, HDGF2, HDGFL2, HDGFRP2, HRP-2, HRP2, Hepatoma-derived growth factor 2, Hepatoma-derived growth factor-related protein 2
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q7Z4V5
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	Hepatoma-derived growth factor-related protein 2 (HDGFL2) is a ~74 kDa protein. Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression. 1. Zhu, X. et al. (2020) Nucleic acids research 48, 6563-6582. PMID: 32459350 2. Baude, A. et al. (2016) Nucleic acids research 44, 2214-26. PMID: 26721387 3. Gao, K. et al. (2015) Biochemical and biophysical research communications 458, 849-55. PMID: 25689719
Note	For research use only

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Anti-Human HDGFL2 Recombinant Nanobody (SAA2783).pdf

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Anti-Human HDGFL2 Recombinant Nanobody (SAA2783) (HA200013)

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