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| 카탈로그 번호 | HC775012 |
|---|---|
| 설명 |
Recombinant Human HTR1F Protein, C-His (HC775012) expressed in E. coli. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P30939 |
| 단백질 길이 | Asp2-Thr29&Leu119-Gly141&Arg162-His178&Lys312-Ser329 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 38.46 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | 5-HT-1F, 5-HT1F, 5-hydroxytryptamine receptor 1F, HTR1EL, HTR1F, Serotonin receptor 1F |
| 배경 | 5-hydroxytryptamine receptor 1F is a ~41 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. 1. Klein, MT. et al. (2011) The Journal of pharmacology and experimental therapeutics 337, 860-7. PMID: 21422162 2. Huang, S. et al. (2021) Cell research 31, 1036-1038. PMID: 34239069 3. Adham, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 408-12. PMID: 8380639 4. Lovenberg, TW. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2184-8. PMID: 8384716 5. Tan, Y. et al. (2022) Cell discovery 8, 50. PMID: 35610220 |
| 참고사항 | For research use only |
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