Human HTR1F Recombinant Protein (C-His) (HC775022)

Name: Human HTR1F Recombinant Protein (C-His)
Brand: abinScience
SKU: HC775022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC775022
Description	Recombinant Human HTR1F Protein, C-His (HC775022) expressed in E. coli, spanning Lys209-Lys290. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P30939
Protein length	Lys209-Lys290
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	37.70 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	5-HT-1F, 5-HT1F, 5-hydroxytryptamine receptor 1F, HTR1EL, HTR1F, Serotonin receptor 1F
Background	5-hydroxytryptamine receptor 1F is a ~41 kDa protein. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Receptor for lasmiditan, a drug for the treatment of acute migraine. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1F is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. 1. Klein, MT. et al. (2011) The Journal of pharmacology and experimental therapeutics 337, 860-7. PMID: 21422162 2. Huang, S. et al. (2021) Cell research 31, 1036-1038. PMID: 34239069 3. Adham, N. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 408-12. PMID: 8380639 4. Lovenberg, TW. et al. (1993) Proceedings of the National Academy of Sciences of the United States of America 90, 2184-8. PMID: 8384716 5. Tan, Y. et al. (2022) Cell discovery 8, 50. PMID: 35610220
Note	For research use only

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Datasheet

Human HTR1F Recombinant Protein (C-His).pdf

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Human HTR1F Recombinant Protein (C-His) (HC775022)

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