Human KPNB1 Recombinant Protein (N-His) (HD617012)

Name: Human KPNB1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD617012
Price: 211 USD
Availability: InStock

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사양:

50ug
100ug
1mg

수량:

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개요
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SDS

개요

카탈로그 번호	HD617012
설명	Recombinant Human KPNB1 Protein, N-His (HD617012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
발현 시스템	E. coli
등록번호	Q14974
단백질 길이	Met1-Ala442
응용 분야	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
종	Homo sapiens (Human)
성질	Recombinant
내독소 수준	Please contact with the lab for this information.
순도	>90% as determined by SDS-PAGE.
형태	Lyophilized
저장 완충액	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
재구성	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
배송	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
대체 이름	Importin subunit beta-1, Importin-90, KPNB1, Karyopherin subunit beta-1, NTF97, Nuclear factor p97, PTAC97, Pore targeting complex 97 kDa subunit
배경	Importin subunit beta-1 is a ~97 kDa protein. Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. 1. Jäkel, S. et al. (1999) The EMBO journal 18, 2411-23. PMID: 10228156 2. Dean, KA. et al. (2001) Journal of cell science 114, 3479-85. PMID: 11682607 3. White, WO. et al. (2002) Journal of cellular biochemistry 85, 42-53. PMID: 11891849 4. Mingot, JM. et al. (2009) Journal of cell science 122, 1452-60. PMID: 19386897 5. Pawłowski, R. et al. (2010) The EMBO journal 29, 3448-58. PMID: 20818336 6. Choi, S. et al. (2014) Acta crystallographica. Section D, Biological crystallography 70, 1050-60. PMID: 24699649 7. Chi, NC. et al. (1995) The Journal of cell biology 130, 265-74. PMID: 7615630 8. Jäkel, S. et al. (1998) The EMBO journal 17, 4491-502. PMID: 9687515
참고사항	For research use only

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Human KPNB1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

재조합 단백질

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Human KPNB1 Recombinant Protein (N-His) (HD617012)

개요

이미지

참고 문헌

데이터시트

SDS

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