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| 카탈로그 번호 | HB966012 |
|---|---|
| 설명 |
Recombinant Human LTK Protein, N-His (HB966012) expressed in E. coli, spanning Ser67-Asn380. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P29376 |
| 단백질 길이 | Ser67-Asn380 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 33.6 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | EC:2.7.10.1, LTK, Leukocyte tyrosine kinase receptor, Protein tyrosine kinase 1, TYK1 |
| 배경 | Leukocyte tyrosine kinase receptor is a ~91 kDa protein. Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. 1. Honda, H. et al. (1999) Oncogene 18, 3821-30. PMID: 10445845 2. Farhan, H. et al. (2010) The Journal of cell biology 189, 997-1011. PMID: 20548102 3. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385 4. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012 5. Yamada, S. et al. (2008) Neuroreport 19, 1733-8. PMID: 18849880 6. Ueno, H. et al. (1997) Oncogene 14, 3067-72. PMID: 9223670 |
| 참고사항 | For research use only |
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