Anti-Human LTK Recombinant Antibody (SAA1618) (HB966013)

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Datasheet

Overview

Catalog No.

HB966013

Description

Anti-Human LTK Antibody (SAA1618) [SAA1618] (HB966013) is a mouse monoclonal antibody detecting LTK in ELISA. Suitable for Human.

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1618

Clonality

Monoclonal

Target

TYK1, Leukocyte tyrosine kinase receptor, LTK, Protein tyrosine kinase 1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P29376

RRID

Anti-Human LTK Antibody (SAA1618) (abinScience Cat# HB966013, RRID:AB_3727379)

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Leukocyte tyrosine kinase receptor (LTK) is a ~91 kDa protein. Receptor with a tyrosine-protein kinase activity. Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response. Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival.

1. Honda, H. et al. (1999) Oncogene 18, 3821-30. PMID: 10445845

2. Farhan, H. et al. (2010) The Journal of cell biology 189, 997-1011. PMID: 20548102

3. Reshetnyak, AV. et al. (2018) Proceedings of the National Academy of Sciences of the United States of America 115, 8340-8345. PMID: 30061385

4. De Munck, S. et al. (2021) Nature 600, 143-147. PMID: 34646012

5. Yamada, S. et al. (2008) Neuroreport 19, 1733-8. PMID: 18849880

6. Ueno, H. et al. (1997) Oncogene 14, 3067-72. PMID: 9223670

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human LTK Antibody (SAA1618)

References

Datasheet

Anti-Human LTK Recombinant Antibody (SAA1618).pdf

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human LTK Recombinant Antibody (SAA1618) (HB966013)

Overview

Images

References

Datasheet

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