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| 카탈로그 번호 | HS892011 |
|---|---|
| 설명 |
Recombinant Human NTRK2 Protein, C-Strep (HS892011) expressed in Mammalian Cells, spanning Cys32-His430. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | Mammalian cells |
| 등록번호 | Q16620 |
| 단백질 길이 | Cys32-His430 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 49.23 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | BDNF/NT-3 growth factors receptor, EC:2.7.10.1, GP145-TrkB, NTRK2, Neurotrophic tyrosine kinase receptor type 2, TRKB, Trk-B, TrkB tyrosine kinase, Tropomyosin-related kinase B |
| 배경 | BDNF/NT-3 growth factors receptor is a ~91 kDa protein. Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. 1. Yeo, GS. et al. (2004) Nature neuroscience 7, 1187-9. PMID: 15494731 2. Haniu, M. et al. (1995) Archives of biochemistry and biophysics 322, 256-64. PMID: 7574684 |
| 참고사항 | For research use only |
Detected by ZEB85 (Catalog No: HS892016) in indirect ELISA.
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중국 우한시 심둔사로 666번지 C동, 우한, 430206
