

| 카탈로그 번호 | HC219012 |
|---|---|
| 설명 |
Recombinant Human PCGF6 Protein, N-His (HC219012) expressed in E. coli, spanning Asp252-Thr350. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q9BYE7 |
| 단백질 길이 | Asp252-Thr350 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 13.33 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | MBLR, Mel18 and Bmi1-like RING finger, PCGF6, Polycomb group RING finger protein 6, RING finger protein 134, RNF134 |
| 배경 | Polycomb group RING finger protein 6 is a ~39 kDa protein. Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. 1. Akasaka, T. et al. (2002) Genes to cells : devoted to molecular & cellular mechanisms 7, 835-50. PMID: 12167161 2. Lee, MG. et al. (2007) Cell 128, 877-87. PMID: 17320162 3. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332 |
| 참고사항 | For research use only |
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