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Anti-Human PCGF6 Polyclonal Antibody (HC219014)

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Overview
Catalog No.HC219014
Description
Anti-Human PCGF6 Polyclonal Antibody (HC219014) is a rabbit polyclonal antibody detecting PCGF6. Suitable for Mouse, Rat, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human PCGF6 (Asp252-Thr350).
Target MBLR, Mel18 and Bmi1-like RING finger, PCGF6, Polycomb group RING finger protein 6, RING finger protein 134, RNF134
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9BYE7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Polycomb group RING finger protein 6 (PCGF6) is a ~39 kDa protein. Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.

1. Akasaka, T. et al. (2002) Genes to cells : devoted to molecular & cellular mechanisms 7, 835-50. PMID: 12167161
2. Lee, MG. et al. (2007) Cell 128, 877-87. PMID: 17320162
3. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332
Note For research use only
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Formula
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V₁ (Stock Vol.)
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Anti-Human PCGF6 Polyclonal Antibody

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