Human PCGF6 Recombinant Protein (N-His) (HC219012)

Name: Human PCGF6 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC219012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HC219012
Description	Recombinant Human PCGF6 Protein, N-His (HC219012) expressed in E. coli, spanning Asp252-Thr350. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q9BYE7
Protein length	Asp252-Thr350
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	13.33 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	MBLR, Mel18 and Bmi1-like RING finger, PCGF6, Polycomb group RING finger protein 6, RING finger protein 134, RNF134
Background	Polycomb group RING finger protein 6 is a ~39 kDa protein. Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. 1. Akasaka, T. et al. (2002) Genes to cells : devoted to molecular & cellular mechanisms 7, 835-50. PMID: 12167161 2. Lee, MG. et al. (2007) Cell 128, 877-87. PMID: 17320162 3. Taherbhoy, AM. et al. (2015) Nature communications 6, 7621. PMID: 26151332
Note	For research use only

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Human PCGF6 Recombinant Protein (N-His).pdf

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Human PCGF6 Recombinant Protein (N-His) (HC219012)

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