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| 카탈로그 번호 | HD651012 |
|---|---|
| 설명 |
Recombinant Human RCC1 Protein, N-His (HD651012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | P18754 |
| 단백질 길이 | Val37-Ser421 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | CHC1, Cell cycle regulatory protein, Chromosome condensation protein 1, RCC1, Regulator of chromosome condensation |
| 배경 | Regulator of chromosome condensation is a ~44 kDa protein. Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. 1. Renault, L. et al. (2001) Cell 105, 245-55. PMID: 11336674 2. Chen, T. et al. (2007) Nature cell biology 9, 596-603. PMID: 17435751 3. Bischoff, FR. et al. (1991) Nature 354, 80-2. PMID: 1944575 4. Tooley, CE. et al. (2010) Nature 466, 1125-8. PMID: 20668449 5. Halpin, D. et al. (2011) PLoS biology 9, e1001225. PMID: 22215983 6. Sankhala, RS. et al. (2017) Nature communications 8, 979. PMID: 29042532 7. Moore, W. et al. (2002) Current biology : CB 12, 1442-7. PMID: 12194828 |
| 참고사항 | For research use only |
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