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| 카탈로그 번호 | HD208012 |
|---|---|
| 설명 |
Recombinant Human THOC5 Protein, N-His (HD208012) expressed in E. coli, spanning His263-Arg683. Purity: >90% by SDS-PAGE.
Highlights
|
| 발현 시스템 | E. coli |
| 등록번호 | Q13769 |
| 단백질 길이 | His263-Arg683 |
| 응용 분야 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 종 | Homo sapiens (Human) |
| 성질 | Recombinant |
| 내독소 수준 | Please contact with the lab for this information. |
| 순도 | >90% as determined by SDS-PAGE. |
| 예측 분자량 | 49.86 kDa |
| 형태 | Lyophilized |
| 저장 완충액 | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요. |
| 재구성 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 배송 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 안정성 및 저장 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 대체 이름 | C22orf19, Functional spliceosome-associated protein 79, KIAA0983, NF2/meningioma region protein pK1.3, PP39.2, Placental protein 39.2, THO complex subunit 5, THOC5, fSAP79, hTREX90 |
| 배경 | THO complex subunit 5 is a ~78 kDa protein. Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. 1. Guo, S. et al. (2005) Cancer research 65, 3011-6. PMID: 15833825 2. Masuda, S. et al. (2005) Genes & development 19, 1512-7. PMID: 15998806 3. Cheng, H. et al. (2006) Cell 127, 1389-400. PMID: 17190602 4. Pühringer, T. et al. (2020) eLife 9. PMID: 33191911 5. Boyne, JR. et al. (2008) PLoS pathogens 4, e1000194. PMID: 18974867 6. Katahira, J. et al. (2013) Nucleic acids research 41, 7060-72. PMID: 23685434 |
| 참고사항 | For research use only |
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