Anti-Human ADCYAP1/PACAP Reference Antibody (Ald1910, RUO) (HB716016)

Name: Anti-Human ADCYAP1/PACAP Reference Antibody (Ald1910, RUO)
Brand: abinScience
SKU: HB716016
Price: 176 USD
Availability: InStock

데이터시트 제품 공유 정보 복사

가격(USD):

사양:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

수량:

문의하기

개요
이미지
참고 문헌
데이터시트
SDS

개요

카탈로그 번호	HB716016
설명	ALD1910 (HB716016) is a research-grade recombinant antibody targeting Pituitary adenylate cyclase-activating polypeptide. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
종 반응성	Human
응용 분야	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
숙주 종	Human
클론성	Monoclonal
이소타입	IgG2
발현 시스템	Mammalian cells
타겟	Pituitary adenylate cyclase-activating polypeptide, ADCYAP1, PACAP, PACAP-38, PACAP38, PACAP-27, PACAP27, PRP-48
내독소 수준	< 10 EU/mg
순도	>95% as determined by SDS-PAGE.
정제	Protein A/G purified from cell culture supernatant.
등록번호	P18509
형태	Liquid
저장 완충액	0.01M PBS pH 7.4. 데이터시트 인쇄본 또는 로트별 COA에 기재된 구체적인 완충액 정보를 참조하세요.
안정성 및 저장	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
배경	Pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. 1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907 2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469 3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270 4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145
참고사항	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG2 Recombinant Isotype Control Antibody (HyHEL-10) (HV988107)